Movement Disorders (revue)

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

Contribution of the interleukin‐1β gene polymorphism in multiple system atrophy

Identifieur interne : 004530 ( Main/Exploration ); précédent : 004529; suivant : 004531

Contribution of the interleukin‐1β gene polymorphism in multiple system atrophy

Auteurs : Masataka Nishimura [Japon] ; Hideshi Kawakami [Japon] ; Osamu Komure [Japon] ; Hirofumi Maruyama [Japon] ; Hiroyuki Morino [Japon] ; Yuishin Izumi [Japon] ; Shigenobu Nakamura [Japon] ; Ryuji Kaji [Japon] ; Sadako Kuno [Japon]

Source :

RBID : ISTEX:3A9FCA6872035A40601C18BCC37B584D7B531BAD

Descripteurs français

English descriptors

Abstract

We studied genetic polymorphisms in the promoter region at position ‐511 of the interleukin (IL) ‐1β gene (IL‐1B‐511) and at position ‐889 of the IL‐1α gene (IL‐1A‐889), in 111 Japanese patients with multiple system atrophy (MSA) and 160 controls. The distribution of IL‐1B‐511 was significantly different between MSA patients and controls, because of the under‐representation of patients with homozygotes for allele 2 (IL‐1B‐511*2), a high producer of IL‐1β. The frequency of IL‐1A‐889*2, a high secretor of IL‐1α, was also decreased in MSA patients. Our findings suggest that abnormal cytokine expression may be implicated in the pathogenesis of MSA. © 2002 Movement Disorder Society

Url:
DOI: 10.1002/mds.10124


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

<record>
<TEI wicri:istexFullTextTei="biblStruct">
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">Contribution of the interleukin‐1β gene polymorphism in multiple system atrophy</title>
<author>
<name sortKey="Nishimura, Masataka" sort="Nishimura, Masataka" uniqKey="Nishimura M" first="Masataka" last="Nishimura">Masataka Nishimura</name>
</author>
<author>
<name sortKey="Kawakami, Hideshi" sort="Kawakami, Hideshi" uniqKey="Kawakami H" first="Hideshi" last="Kawakami">Hideshi Kawakami</name>
</author>
<author>
<name sortKey="Komure, Osamu" sort="Komure, Osamu" uniqKey="Komure O" first="Osamu" last="Komure">Osamu Komure</name>
</author>
<author>
<name sortKey="Maruyama, Hirofumi" sort="Maruyama, Hirofumi" uniqKey="Maruyama H" first="Hirofumi" last="Maruyama">Hirofumi Maruyama</name>
</author>
<author>
<name sortKey="Morino, Hiroyuki" sort="Morino, Hiroyuki" uniqKey="Morino H" first="Hiroyuki" last="Morino">Hiroyuki Morino</name>
</author>
<author>
<name sortKey="Izumi, Yuishin" sort="Izumi, Yuishin" uniqKey="Izumi Y" first="Yuishin" last="Izumi">Yuishin Izumi</name>
</author>
<author>
<name sortKey="Nakamura, Shigenobu" sort="Nakamura, Shigenobu" uniqKey="Nakamura S" first="Shigenobu" last="Nakamura">Shigenobu Nakamura</name>
</author>
<author>
<name sortKey="Kaji, Ryuji" sort="Kaji, Ryuji" uniqKey="Kaji R" first="Ryuji" last="Kaji">Ryuji Kaji</name>
</author>
<author>
<name sortKey="Kuno, Sadako" sort="Kuno, Sadako" uniqKey="Kuno S" first="Sadako" last="Kuno">Sadako Kuno</name>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:3A9FCA6872035A40601C18BCC37B584D7B531BAD</idno>
<date when="2002" year="2002">2002</date>
<idno type="doi">10.1002/mds.10124</idno>
<idno type="url">https://api.istex.fr/document/3A9FCA6872035A40601C18BCC37B584D7B531BAD/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">002E83</idno>
<idno type="wicri:Area/Istex/Curation">002E83</idno>
<idno type="wicri:Area/Istex/Checkpoint">002E22</idno>
<idno type="wicri:doubleKey">0885-3185:2002:Nishimura M:contribution:of:the</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:12210881</idno>
<idno type="wicri:Area/PubMed/Corpus">003A05</idno>
<idno type="wicri:Area/PubMed/Curation">003A05</idno>
<idno type="wicri:Area/PubMed/Checkpoint">003B52</idno>
<idno type="wicri:Area/Ncbi/Merge">000846</idno>
<idno type="wicri:Area/Ncbi/Curation">000846</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000846</idno>
<idno type="wicri:doubleKey">0885-3185:2002:Nishimura M:contribution:of:the</idno>
<idno type="wicri:Area/Main/Merge">006536</idno>
<idno type="wicri:source">INIST</idno>
<idno type="RBID">Pascal:02-0456877</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">002680</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000641</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">002820</idno>
<idno type="wicri:doubleKey">0885-3185:2002:Nishimura M:contribution:of:the</idno>
<idno type="wicri:Area/Main/Merge">006859</idno>
<idno type="wicri:Area/Main/Curation">004530</idno>
<idno type="wicri:Area/Main/Exploration">004530</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title level="a" type="main" xml:lang="en">Contribution of the interleukin‐1β gene polymorphism in multiple system atrophy</title>
<author>
<name sortKey="Nishimura, Masataka" sort="Nishimura, Masataka" uniqKey="Nishimura M" first="Masataka" last="Nishimura">Masataka Nishimura</name>
<affiliation wicri:level="1">
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Clinical Neuroscience, Tokushima University Hospital, Tokushima</wicri:regionArea>
<wicri:noRegion>Tokushima</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Kawakami, Hideshi" sort="Kawakami, Hideshi" uniqKey="Kawakami H" first="Hideshi" last="Kawakami">Hideshi Kawakami</name>
<affiliation wicri:level="1">
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Third Department of Internal Medicine, Hiroshima University School of Medicine, Hiroshima</wicri:regionArea>
<wicri:noRegion>Hiroshima</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Komure, Osamu" sort="Komure, Osamu" uniqKey="Komure O" first="Osamu" last="Komure">Osamu Komure</name>
<affiliation wicri:level="1">
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Neurology and Clinical Research Center, Utano National Hospital, Kyoto</wicri:regionArea>
<wicri:noRegion>Kyoto</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Maruyama, Hirofumi" sort="Maruyama, Hirofumi" uniqKey="Maruyama H" first="Hirofumi" last="Maruyama">Hirofumi Maruyama</name>
<affiliation wicri:level="1">
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Third Department of Internal Medicine, Hiroshima University School of Medicine, Hiroshima</wicri:regionArea>
<wicri:noRegion>Hiroshima</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Morino, Hiroyuki" sort="Morino, Hiroyuki" uniqKey="Morino H" first="Hiroyuki" last="Morino">Hiroyuki Morino</name>
<affiliation wicri:level="1">
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Third Department of Internal Medicine, Hiroshima University School of Medicine, Hiroshima</wicri:regionArea>
<wicri:noRegion>Hiroshima</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Izumi, Yuishin" sort="Izumi, Yuishin" uniqKey="Izumi Y" first="Yuishin" last="Izumi">Yuishin Izumi</name>
<affiliation wicri:level="1">
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Clinical Neuroscience, Tokushima University Hospital, Tokushima</wicri:regionArea>
<wicri:noRegion>Tokushima</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Nakamura, Shigenobu" sort="Nakamura, Shigenobu" uniqKey="Nakamura S" first="Shigenobu" last="Nakamura">Shigenobu Nakamura</name>
<affiliation wicri:level="1">
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Third Department of Internal Medicine, Hiroshima University School of Medicine, Hiroshima</wicri:regionArea>
<wicri:noRegion>Hiroshima</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Kaji, Ryuji" sort="Kaji, Ryuji" uniqKey="Kaji R" first="Ryuji" last="Kaji">Ryuji Kaji</name>
<affiliation wicri:level="1">
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Clinical Neuroscience, Tokushima University Hospital, Tokushima</wicri:regionArea>
<wicri:noRegion>Tokushima</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Kuno, Sadako" sort="Kuno, Sadako" uniqKey="Kuno S" first="Sadako" last="Kuno">Sadako Kuno</name>
<affiliation wicri:level="1">
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Neurology and Clinical Research Center, Utano National Hospital, Kyoto</wicri:regionArea>
<wicri:noRegion>Kyoto</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series>
<title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint>
<publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>New York</pubPlace>
<date type="published" when="2002-07">2002-07</date>
<biblScope unit="vol">17</biblScope>
<biblScope unit="issue">4</biblScope>
<biblScope unit="page" from="808">808</biblScope>
<biblScope unit="page" to="811">811</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">3A9FCA6872035A40601C18BCC37B584D7B531BAD</idno>
<idno type="DOI">10.1002/mds.10124</idno>
<idno type="ArticleID">MDS10124</idno>
</biblStruct>
</sourceDesc>
<seriesStmt>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Alleles</term>
<term>Female</term>
<term>Gene</term>
<term>Gene Frequency (genetics)</term>
<term>Genetic determinism</term>
<term>Genotype</term>
<term>Humans</term>
<term>IL‐1α</term>
<term>IL‐1β</term>
<term>Interleukin 1α</term>
<term>Interleukin 1β</term>
<term>Interleukin-1 (genetics)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multiple System Atrophy (genetics)</term>
<term>Multiple system atrophy</term>
<term>Polymorphism</term>
<term>Polymorphism, Genetic (genetics)</term>
<term>Promoter</term>
<term>Promoter Regions, Genetic</term>
<term>Reference Values</term>
<term>multiple system atrophy</term>
<term>polymorphism</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en">
<term>Interleukin-1</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en">
<term>Gene Frequency</term>
<term>Multiple System Atrophy</term>
<term>Polymorphism, Genetic</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Alleles</term>
<term>Female</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Promoter Regions, Genetic</term>
<term>Reference Values</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr">
<term>Adulte</term>
<term>Atrophie multisystématisée</term>
<term>Déterminisme génétique</term>
<term>Gène</term>
<term>Interleukine 1α</term>
<term>Interleukine 1β</term>
<term>Polymorphisme</term>
<term>Promoteur</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr">
<term>Adulte</term>
</keywords>
</textClass>
<langUsage>
<language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">We studied genetic polymorphisms in the promoter region at position ‐511 of the interleukin (IL) ‐1β gene (IL‐1B‐511) and at position ‐889 of the IL‐1α gene (IL‐1A‐889), in 111 Japanese patients with multiple system atrophy (MSA) and 160 controls. The distribution of IL‐1B‐511 was significantly different between MSA patients and controls, because of the under‐representation of patients with homozygotes for allele 2 (IL‐1B‐511*2), a high producer of IL‐1β. The frequency of IL‐1A‐889*2, a high secretor of IL‐1α, was also decreased in MSA patients. Our findings suggest that abnormal cytokine expression may be implicated in the pathogenesis of MSA. © 2002 Movement Disorder Society</div>
</front>
</TEI>
<affiliations>
<list>
<country>
<li>Japon</li>
</country>
</list>
<tree>
<country name="Japon">
<noRegion>
<name sortKey="Nishimura, Masataka" sort="Nishimura, Masataka" uniqKey="Nishimura M" first="Masataka" last="Nishimura">Masataka Nishimura</name>
</noRegion>
<name sortKey="Izumi, Yuishin" sort="Izumi, Yuishin" uniqKey="Izumi Y" first="Yuishin" last="Izumi">Yuishin Izumi</name>
<name sortKey="Kaji, Ryuji" sort="Kaji, Ryuji" uniqKey="Kaji R" first="Ryuji" last="Kaji">Ryuji Kaji</name>
<name sortKey="Kawakami, Hideshi" sort="Kawakami, Hideshi" uniqKey="Kawakami H" first="Hideshi" last="Kawakami">Hideshi Kawakami</name>
<name sortKey="Komure, Osamu" sort="Komure, Osamu" uniqKey="Komure O" first="Osamu" last="Komure">Osamu Komure</name>
<name sortKey="Kuno, Sadako" sort="Kuno, Sadako" uniqKey="Kuno S" first="Sadako" last="Kuno">Sadako Kuno</name>
<name sortKey="Maruyama, Hirofumi" sort="Maruyama, Hirofumi" uniqKey="Maruyama H" first="Hirofumi" last="Maruyama">Hirofumi Maruyama</name>
<name sortKey="Morino, Hiroyuki" sort="Morino, Hiroyuki" uniqKey="Morino H" first="Hiroyuki" last="Morino">Hiroyuki Morino</name>
<name sortKey="Nakamura, Shigenobu" sort="Nakamura, Shigenobu" uniqKey="Nakamura S" first="Shigenobu" last="Nakamura">Shigenobu Nakamura</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004530 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004530 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     ISTEX:3A9FCA6872035A40601C18BCC37B584D7B531BAD
   |texte=   Contribution of the interleukin‐1β gene polymorphism in multiple system atrophy
}}

Wicri

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024