Contribution of the interleukin‐1β gene polymorphism in multiple system atrophy
Identifieur interne : 004530 ( Main/Exploration ); précédent : 004529; suivant : 004531Contribution of the interleukin‐1β gene polymorphism in multiple system atrophy
Auteurs : Masataka Nishimura [Japon] ; Hideshi Kawakami [Japon] ; Osamu Komure [Japon] ; Hirofumi Maruyama [Japon] ; Hiroyuki Morino [Japon] ; Yuishin Izumi [Japon] ; Shigenobu Nakamura [Japon] ; Ryuji Kaji [Japon] ; Sadako Kuno [Japon]Source :
- Movement Disorders [ 0885-3185 ] ; 2002-07.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Adulte.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Alleles, Female, Gene, Gene Frequency (genetics), Genetic determinism, Genotype, Humans, IL‐1α, IL‐1β, Interleukin 1α, Interleukin 1β, Interleukin-1 (genetics), Male, Middle Aged, Multiple System Atrophy (genetics), Multiple system atrophy, Polymorphism, Polymorphism, Genetic (genetics), Promoter, Promoter Regions, Genetic, Reference Values, multiple system atrophy, polymorphism.
- MESH :
- chemical , genetics : Interleukin-1.
- genetics : Gene Frequency, Multiple System Atrophy, Polymorphism, Genetic.
- Aged, Aged, 80 and over, Alleles, Female, Genotype, Humans, Male, Middle Aged, Promoter Regions, Genetic, Reference Values.
Abstract
We studied genetic polymorphisms in the promoter region at position ‐511 of the interleukin (IL) ‐1β gene (IL‐1B‐511) and at position ‐889 of the IL‐1α gene (IL‐1A‐889), in 111 Japanese patients with multiple system atrophy (MSA) and 160 controls. The distribution of IL‐1B‐511 was significantly different between MSA patients and controls, because of the under‐representation of patients with homozygotes for allele 2 (IL‐1B‐511*2), a high producer of IL‐1β. The frequency of IL‐1A‐889*2, a high secretor of IL‐1α, was also decreased in MSA patients. Our findings suggest that abnormal cytokine expression may be implicated in the pathogenesis of MSA. © 2002 Movement Disorder Society
Url:
DOI: 10.1002/mds.10124
Affiliations:
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<term>Gene</term>
<term>Gene Frequency (genetics)</term>
<term>Genetic determinism</term>
<term>Genotype</term>
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<term>IL‐1α</term>
<term>IL‐1β</term>
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<term>Interleukin 1β</term>
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<term>Male</term>
<term>Middle Aged</term>
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<term>Promoter Regions, Genetic</term>
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<front><div type="abstract" xml:lang="en">We studied genetic polymorphisms in the promoter region at position ‐511 of the interleukin (IL) ‐1β gene (IL‐1B‐511) and at position ‐889 of the IL‐1α gene (IL‐1A‐889), in 111 Japanese patients with multiple system atrophy (MSA) and 160 controls. The distribution of IL‐1B‐511 was significantly different between MSA patients and controls, because of the under‐representation of patients with homozygotes for allele 2 (IL‐1B‐511*2), a high producer of IL‐1β. The frequency of IL‐1A‐889*2, a high secretor of IL‐1α, was also decreased in MSA patients. Our findings suggest that abnormal cytokine expression may be implicated in the pathogenesis of MSA. © 2002 Movement Disorder Society</div>
</front>
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<name sortKey="Izumi, Yuishin" sort="Izumi, Yuishin" uniqKey="Izumi Y" first="Yuishin" last="Izumi">Yuishin Izumi</name>
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<name sortKey="Morino, Hiroyuki" sort="Morino, Hiroyuki" uniqKey="Morino H" first="Hiroyuki" last="Morino">Hiroyuki Morino</name>
<name sortKey="Nakamura, Shigenobu" sort="Nakamura, Shigenobu" uniqKey="Nakamura S" first="Shigenobu" last="Nakamura">Shigenobu Nakamura</name>
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